can diabetes be cured ? news for type 1 diabetes
For many years it was considered conventional wisdom that type 2 diabetes comes with many options for cure and prevention. Yet, for those unfortunate with type 1 there was no real alternative known to medical science besides dealing with the side effects. Now, it seems this knowledge may be going to change, and the answer to those who wonder can diabetes be cured may be happily different.
So, what has changed ?
A team of leading scientists from Harvard University discovered lately how to help produce significant quantities of insulin producing cells. This breakthrough is hailed in the professional community as no less tantamount to the discovery of antibiotics.
What the team at Harvard has actually achieved is, for the first time managed manufacture of millions of beta cells crucial for transplantation. They used embryonic stem cells to produce human insulin producing cells, equivalent in most respects to normally functioning cells in vast quantities.
If this proves practical to be repeated on demand over and over again, this could mean the end of daily insulin injections for the millions of youngsters and adults all over the world living with Type 1 diabetes today.
When interviewed, professor Doug Melton of Harvard said: “We are now just one pre clinical step away from the finish line”.
And there is a very personal angle to this as well: professor Melton has been working to find a cure for the disease for twenty three years, since his son Sam was diagnosed with Type 1 diabetes as a baby. About this all he could say was: "I think like all kids, they always assumed that if I said I'd do this, I'd do it,
"It was gratifying to know that we can do something that we always thought was possible.”
What are the next stages, and when will this solution be actually available ?
Unfortunately, Type 1 Diabetics will still have to be patient. The stem cell derived beta cells are already undergoing trials in animal. These, include non human primates, where they are still producing insulin after several months, Prof Melton added.
Type 1 diabetes is recognized as an autoimmune condition. It manifests in the pancreas ceased production of insulin – the critical hormone needed to regulate the blood glucose levels.
One of the major side effects of diabetes is when the blood glucose reaches too high. Then, it might seriously damage various internal organs and blood circulation over time.
Why is this so significant when diabetics can manage blood sugar levels with injections, diet, exercise etc. ?
Well, while people with diabetes can generally keep their glucose levels under control by injecting insulin, it is not sufficient for the fine tuning necessary to properly control metabolism. The resulting highs and lows may lead to devastating complications, such as blindness and amputations of limbs.
Moreover, there is to consider: Type 1 diabetes currently represents about 10 percents of all diabetics. Yet, sadly enough it is the most common type of childhood diabetes, thus affecting whole generations.
Another researcher, Professor Chris Mason from University College in London, described this as "potentially a major medical breakthrough." He also had this to add: “If this scalable technology is proven to work, in both the clinic and in the manufacturing facility, the impact on the treatment of diabetes will be a medical game-changer on a par with antibiotics and bacterial infections”.
The report is published in the leading journal "Cell".
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